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Known as 逆時針 or “Time Reversing Injection”, Profhilo is the latest multi-purpose injectable treatment for skin rejuvenation, hydration and collagen stimulation.

Founded in Italy, Profhilo has been widely used in the world since 2015, but for several years, its use has been limited to Europe. The extremely well-reviewed skin injective treatment has recently received our HSA approval in 2020, and is quickly gaining popularity and has become the choice of aesthetic treatment in Singapore. 


  • Bio-stimulates elastic, 4 types of collagen and hydration in the 3 main layers of the skin

  • Provides firming, tightening and lifting effects to the skin

  • Improve overall skin quality and hydration

  • Fast and effective treatment with minimal pain and downtime

  • Provides tissue repair process, ideal for acne scarring


Profhilo is suitable for anyone who is looking to improve their skin.

It works especially well for anyone with signs of ageing skin looking to hydrate, tighten, and improve the quality of their skin. It is most effective for mild to moderate cases of skin laxity and fine lines.

*The treatment is also suitable for men’s thicker skin, without the effect of softening their masculine features.


Profhilo is a skin injectable treatment that delivers hyaluronic acid to all the layers of the skin. Although Profhilo’s main ingredient is similar to that of fillers and skinboosters, the hyaluronic acid in Profhilo is significantly different in both concentration and structure.

Firstly, the concentration of hyaluronic acid in Profhilo is about 5 times more than the average skinbooster, making it a skin injectable with the highest concentration of hyaluronic acid in the world.

Secondly, the chemical structure of hyaluronic acid in Profhilo is also distinct from that of other injectable treatments. Most cross linked hyaluronic acids before Profhilo contains a chemical cross-linking agent, called 1,4-butanediol diglycidyl ether (BDDE). Hyaluronic acid in Profhilo, on the other hand, is thermally cross-linked to form a type of molecule called Hybrid Cooperative Complex (HCC).

The result of this is the ability of Profhilo to ‘bio-remodel’ the skin tissue, improving hydration and skin firmness through collagen production. This also allows hyaluronic acids of high and low molecular weight to link together, allowing them to release slowly and dissipate evenly under the skin.

*In addition, it does not contain additives such as BDDE or Lycodine. With this unique production process, the injected substance spreads extensively and minimises the risk of lumpiness.



The key advantage of the Profhilo treatment, as compared to other skin injection treatments, is the number of injection sites required.

With other skin injection treatments, multiple injections are required to distribute the product around the whole face.

However, with Profhilo, due to its unique structure and spreadability under the skin, the number of injection sites is only five on each side of the face and neck using The Bio Aesthetic Point (BAP) technique.

5 BAP.tif


The Bio Aesthetic Points (BAP) technique are five injections points on the face chosen due to their safety with the absence of large, critical vessels and nerve branches. This means that risks are minimized and favorable effects would be minimized

Profhilo is suitable for anyone who is looking to improve their skin. It works especially well for anyone with signs of ageing skin looking to hydrate, tighten, and improve the quality of their skin. It is most effective for mild to moderate cases of skin laxity and fine lines.

Profhilo® is the first to combine the enhanced hydrating effects and the stronger regenerative effects of different types of HA-based products without the use of additional chemical stabilising agents.

This reduces unwanted side effects and makes it far safer compared to other products.

Patients can expect to see good results usually after their second treatment, which is typically a month after the first session. However, some patients can see results after the first treatment.

To achieve the best long-lasting results for Profhilo, you will need two treatments that are four-weeks apart. This treatment can be repeated after six months in cases where more repair is desired.

There may be some minor pain and discomfort during the injection. This should be minimal as the needle used is relatively thin (29g). Other than this, the treatment should be relatively painless.

Profhilo® has almost no visible side effects as the 100% pure HA used is completely harmless.

However, Some may experience mild redness and soreness after the treatment, but these will usually subside in a few hours.

There is usually no downtime after treatment with Profhilo® and patients can typically resume their daily activities immediately after the treatment.

Patients only need to attend a second follow-up session a month after the initial treatment.

Anyone who is suitable for standard dermal filler treatment is suitable for Profhilo® as it is safer than most other HA-based treatments for skin aging.

However, because everyone unique skin conditions, please consult the doctor before commencing treatment.

Yes, Profhilo® treatment can be combined with other treatments.

However, do inform us of these products/treatments so we can advise accordingly.