NUCLEOFILL | VIDASKIN Medical Aesthetic Clinic

Address: 501 Orchard Road #04-05 Wheelock Place Singapore 238880


The “Nucleofill” biostimulating, high viscosity, polynucleotide-based, natural gels from “Promoitalia Medical Aesthetics” intended for skin protection and rejuvenation, is an effective tool for ANTI-AGING therapy.

Nucleofill™ biorestructuring gel efficiency is structured on low molecular weight, purified, naturally occurring polynucleotides that are specifically designed to improve the trophism of the periocular (eye) area, and to tighten and firm the skin. The polynucleotides work to moisturize, reduce free radical damage and boost collagen production.


What Is Nucleofill™?

Nucleofill™ is an injectable bio-remodeling treatment that uses polynucleotides to stimulate collagen and elastin production in the skin while providing long-lasting hydration and antioxidant support.

The biocompatible polynucleotides in Nucleofill rebuild the skin in 3 ways:

  • Boosting the production of collagen through the activation of fibroblast activity
  • Binding with water molecules to provide lasting hydration within the dermal matrix
  • Neutralizing harmful free radicals

Nucleofill™ Contains a Pure Concentration Of Polynucleotides

Polynucleotides are fragments of DNA and RNA present in all living organisms. Biocompatible with the human body, high molecular weight polynucleotides work within the dermal matrix to stimulate fibroblast activity and rebuild skin tissue. Polynucleotides are also associated with tissue hydration, as they can attach a large number of water molecules. Their antioxidant action combats free radicals and protects the skin from the effects of photoaging. Unlike fillers, Nucleofill™ is a bio-remodeling treatment that stimulates the skin to rejuvenate itself.  


What Is Biostimulation?

Biostimulation involves the injection of natural substances into the skin, so as to counter the loss of skin elasticity and tension. These natural substances are high-viscosity polynucleotides that have aesthetically significant biochemical properties. Deep stimulation of the elastin and collagen production functions helps amplify naturally occurring processes, thereby kickstarting youthful skin regeneration.

Through biostimulation, you can expect some of these benefits:

  1. Reducing loose and saggy skin around the neck, cheeks and eyebags
  2. Improve skin tone and elasticity through augmented collagen production
  3. Increase the hydration retention capacity of the skin
  4. Minimize the damaging effects caused by sun exposure

The mechanisms behind biostimulation are well-studied, but there are disparities between the specific treatment options on the market today. At VIDASKIN, we offer our clients the option of Nucleofill biostimulation because we believe the scientific efficacy and safety of this product is solidly established.


Nucleofill™ Biostimulation

Nucleofill™ is a CE-approved treatment option that has been regarded as “skin bioregeneration”. It aims to achieve 3 outcomes through a single polynucleotide injection:

  1. Deep Moisturizing Effect. Nucleofill™ has strong moisturizing capacity that can be traced back to the polynucleotides’ ability to bind water molecules at the cellular level. The hydration retention effect of Nucleofill allows the skin to remain moisturized for long periods of time.

  2. Biostimulating Effect. Nucleofill™'s polynucleotides are also designed to activate specific membrane receptors on fibroblasts, leading to increased collagen production which improves skin elasticity. Moreover, these polynucleotides are also involved in augmenting the myofibroblasts in the skin which provides a strong skin lifting effect.

  3. Antioxidant Effect. Nucleofill™ also acts as a radical scavenger by eliminating the occurrence of free radicals in the skin. Its strong antioxidant effects protect collagen fibers and the skin’s protective layers from being damaged.


3 Main Actions You'll See With Nucleofill™

Strengthening & Lifting Action The polynucleotides in Nucleofill have a twofold bio-stimulating effect:

  • They activate fibroblasts to boost type I collagen and elastin production, which improves skin elasticity

  • They are associated with the maturation of fibroblasts within myofibroblasts, which has a lifting and strengthening effect on the skin.

Hydrating & Antioxidant Action

  • Polynucleotides work within the dermal matrix by binding to water molecules and providing longer-lasting moisture.

  • Nucleofill™ has strong antioxidant properties that play a critical part in eliminating free radicals and shielding the skin from further damage.


Nucleofill™ Treatment Regime

Dr Vicki will analyze and assess your skin condition and needs to determine the specific areas for treatment. Nucleofill™ can be used on its own or combine with other treatments for the best results. Once an anesthetic cream has been applied to numb the area, the Nucleofill™ is injected at 5 Bio Aesthetic Points (BAP) on each side of the face.

For optimal results, Nucleofill™ treatments are carried out in a series of 3 to 4 treatments, with an interval of 2-4 weeks between each treatment.


Key Benefits Of Nucleofill™

After a few sessions, you may notice the skin becoming firmer and more moisturized. There will be visible improvements in the skin elasticity as well. Wrinkles may be smoothed out, while cheeks appear more plump.

Notice these improvements :

  • Revitalizes and lifts the skin
  • Moisturizes dehydrated, tired skin
  • Improves skin density and elasticity
  • Firmer and more contoured visage
  • Improves fine lines and wrinkles
  • Eliminates free radicals in the skin

Stronger Dermis With Nucleofill™

The maturation of fibroblasts in myofibroblasts and the production of collagen determines a strong specific lifting and revitalizing effect suitable for all skin types. By promoting the metabolic activity of the fibroblastic cells, polynucleotides collaborate to reintegrate into the dermis various fundamental autologous components (glucoseaminoglycans, proteins, glycoproteins, fibrils, etc.) tending to maintain their physiological functionality.

Their repeated administration over time, determines:

  • A protracted isosmotic hydration of the dermal matrix
  • An anti-radical action

Both of these effects combine to recreate in the dermal matrix the most favorable physiological conditions for the regeneration and metabolic activity of fibroblasts, with long-lasting biorevitalizing effects.


Nucleofill™: A Specific Mechanism Of Action For Optimal Biorevitalization

Polynucleotides activate two types of membrane receptors in fibroblasts, or rather:

• Receptor CD39

• Receptor CD40

The activation of these receptors lead to two effects:

• Stimulation of type I collagen production

• Maturation of fibroblasts in myofibroblasts


What Are The Associated Risks of Nucleofill™ – Is It Safe For Me?

Nucleofill™ is suitable for most individuals seeking aesthetic treatments. However, at-risk individuals such as those suffering from cancers, skin infections or blood diseases should avoid Nucleofill. Our aesthetic doctor will carefully assess your eligibility on a case-by-case basis during a consultation.

Most patients experience the Nucleofill™ treatment with minimal or no pain at all. Nevertheless, a simple topical numbing cream would relieve any pain. It is normal to observe some light bruising and/or swelling at the injection sites, but they would naturally go away after some time. There is practically no downtime to this procedure, allowing you to immediately return to your daily activities.


Who Will Be Suitable For Nucleofill™ Treatment?

Nucleofill™ is ideal for men and women over 25, who begin to notice the first signs of aging, such as the loss of volume and appearance of fine lines and wrinkles, and who wish to tighten, hydrate, and improve the quality of their skin. In the case of acne scarring, treatment can be started at an earlier age.

Nucleofill™ treatments address the following conditions:

  • Dehydrated, dull skin
  • Loss of skin tension and strength with poor cicrculation
  • Skin exposed to oxidative stress
  • Visible signs of aging, including skin laxity
  • For those who want firming and contouring, more definition
  • Scars
  • Bio-stimulation and increase in collagen type 1
  • Stretch marks


Is This A Comfortable Treatment?

Topical anesthetic cream is applied to numb the treatment area, minimizing any sensations of the injection.

Most patients experience a mild sensation and temporary unease, which is relative individual tolerance to fine injections. The injections sting briefly, and there may be swelling and mild soreness around the injection points for 1 to 3 days.

Are Results Long-Lasting?

The lifting effect of the treatment generally lasts up to 18 months.


Does Nucleofill™ Have Any Side Effects? 

Some transient swelling can be expected at the injection points, but this will usually settle within a day. Bruising may occur, as is the case with all injectable treatments, and should fade within 14 days.

Is Nucleofill™ Considered An Anti-Aging Treatment?

Containing pure polynucleotides, Nucleofill works at a cellular level to rejuvenate the skin by boosting hydration and stimulating collagen and elastin synthesis. The polynucleotides also contribute to the maturation of myofibroblasts in the skin, which helps lifting effect. As a result of these bio-remodeling processes that occur within the dermis, skin becomes firmer, better hydrated, and more elastic. Moreover, polynucleotides combat free radicals that are associated with the signs of aging.    


Nucleofill™ Vs Profhilo™

The way in which Nucleofill™ differs from familiar injectables such as Profhilo™ is that it’s a bio-stimulant gel, rather than hyaluronic acid. Yet it still does the all-important job of stimulating fibroblasts – the major cells responsible for the production of collagen. Nucleofill™ directly stimulates specific receptors on the fibroblast cells and produces the healthy collagen that we have in our youth. While both treatments are highly effective, they each have their own ideal candidate. Nucleofill™ is fantastic for the more mature age group as it regenerates sagging and dehydrated skin and thickens the tissues. It also lasts longer than Profhilo – up to a year after two treatments.

Ultimately the decision depends on your concerns and your treatment goals. The effect of Profhilo™ is largely glow-giving. Richly hydrating the skin changes its light-reflecting properties, giving your complexion a radiance that no highlighter can match. Nucleofill™ is used for patients who are concerned with fine lines and wrinkles and loss of elasticity on the face or neck. Nucleofill™ treats various indications, making it a good option for under-eye crepiness, wrinkles, and hollows. We can combine these treatments if desired, or use just the one.


Get Your Second Skin

When it comes to your skin, leave no room for regrets. Treat skin laxity and improve your skin health comfortably with Nucleofill™.

As with all aesthetic treatments, a skin analysis is the first step to take. We recommend that you come by for a nonobligatory consultation with Dr.Vicki to better understand how you can benefit from these treatments. However, if you do not have the time to spare, you may send us some photos and we will do our best to advise accordingly.